| Date | Location | Result | |
| 3/17/22 | Buffalo, N.Y. (KeyBank Cener) | Providence 66, South Dakota St. 57 | Box score |
| 3/8/22 | Sioux Falls, S.D. (Premier Center) | South Dakota St. 75, North Dakota St. 69 | Box score |
| 3/7/22 | Sioux Falls, S.D. (Premier Center) | South Dakota St. 83, South Dakota 60 | Box score |
| 3/5/22 | Sioux Falls, S.D. (Premier Center) | South Dakota State 87, Omaha 79 | Box score |
| 2/26/22 | Kansas City, Mo. (Swinney Rec Center) | South Dakota State 86, Kansas City 75 | Box score |
| 2/24/22 | Tulsa, Okla. (Mabee Center) | South Dakota St. 106, Oral Roberts 102 (OT) | Box score |
| 2/19/22 | Brookings, S.D. (Frost Arena) | South Dakota St. 79, St. Thomas (MN) 60 | Box score |
| 2/17/22 | Brookings, S.D. (Frost Arena) | South Dakota St. 91, Western Ill. 66 | Box score |
| 2/12/22 | Brookings, S.D. (Frost Arena) | South Dakota St. 82, Omaha 61 | Box score |
| 2/10/22 | Denver, Colo. (Hamilton Gymnasium) | South Dakota St. 84, Denver 61 | Box score |
| 2/5/22 | Vermillion, S.D. (Coyote Sports Center) | South Dakota St. 89, South Dakota 79 | Box score |
| 1/31/22 | Grand Forks, N.D. (Betty Engelstad Ctr.) | South Dakota St. 70, North Dakota 64 | Box score |
| 1/29/22 | Brookings, S.D. (Frost Arena) | South Dakota St. 80, North Dakota St. 76 | Box score |
| 1/27/22 | Brookings, S.D. (Frost Arena) | South Dakota St. 96, North Dakota 61 | Box score |
| 1/22/22 | Macomb, Ill. (Western Hall) | South Dakota St. 93, Western Ill. 75 | Box score |
| 1/20/22 | St. Paul, Minn. (Schoenecker Arena) | South Dakota St. 92, St. Thomas (MN) 77 | Box score |
| 1/15/22 | Brookings, S.D. (Frost Arena) | South Dakota St. 80, Denver 62 | Box score |
| 1/13/22 | Omaha, Neb. (Baxter Arena) | South Dakota St. 95, Omaha 86 | Box score |
| 1/8/2022 | Brookings, S.D. (Frost Arena) | South Dakota St. 84, South Dakota 65 | Box score |
| 12/30/21 | Fargo, N.D. (Scheels Center) | South Dakota St. 90, North Dakota St. 86 | Box score |
| 12/22/21 | Brookings, S.D. (Frost Arena) | South Dakota St. 82, Oral Roberts 76 | Box score |
| 12/20/21 | Brookings, S.D. (Frost Arena) | South Dakota St. 89, Kansas City 57 | Box score |
| 12/15/21 | Springfield, Mo. (JQH Arena) | Missouri St. 75, South Dakota St. 63 | Box score |
| 12/11/21 | Spokane, Wash. (Spokane Arena) | South Dakota St. 77, Washington St. 74 | Box score |
| 12/8/21 | Moscow, Idaho | Idaho 98, South Dakota St. 84 | Box score |
| 12/3/21 | Brookings, S.D. (Frost Arena) | South Dakota St. 112, Minn.-Morris 47 | Box score |
| 11/30/21 | Brookings, S.D. (Frost Arena) | South Dakota St. 99, Prairie View 90 | Box score |
| 11/24/21 | Sioux Falls, S.D. (Sanford Pentagon) | South Dakota St. 80, George Mason 76 | Box score |
| 11/23/21 | Sioux Falls, S.D. (Sanford Pentagon) | Washington 87, South Dakota St. 76 | Box score |
| 11/22/21 | Sioux Falls, S.D. (Sanford Pentagon) | South Dakota St. 102, Nevada 75 | Box score |
| 11/18/21 | Brookings, S.D. (Frost Arena) | South Dakota St. 99, Presentation 62 | Box score |
| 11/17/21 | Brookings, S.D. (Frost Arena) | South Dakota St. 91, Montana St. 74 | Box score |
| 11/14/21 | Nacogdoches, Texas | South Dakota St. 83, SFA 71 | Box score |
| 11/12/21 | Tuscaloosa, Ala. (Coleman Coliseum) | Alabama 104, South Dakota St. 88 | Box score |
| 11/9/21 | Brookings, S.D. (Frost Arena) | South Dakota St. 81, Bradley 65 | Box score |